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N: Generalized term for a resident of Massachusetts......has evolved to mean any obnoxious loudmouth. The most genuine Massholes are so ignorant and belligerent that they think Masshole is a compliment.

A Masshole takes pride in his aggressive and illegal driving habits. They are too cool to use turn signals. They will nearly wreck you as they cut you off pulling out of the local strip mall, and then drive 30 miles an hour in a 55 zone while they try to light their cigarette while screaming at their children.

A Masshole's car could be a brand new BMW or a beat up 88 Chevy Caprice. It will probably have a "My Kid is an Honor Student" sticker and a sticker endorsing some Irish or Italian local politician you've never heard of.

Massholes infest the nicer northern states of New Hampshire, Vermont, and Maine during the summer months and, ironically, do nothing but complain about the lack of malls once they get there.
For Christmas, Santa brings New Hampshire thousands of Massholes on vacation.
Masshole by FrankGrimes August 14, 2005
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pussyhole 

A slang commonly used in Jamaica generally for backstabbers or guys how gets rich and switch. Otherwise, it is an all purpose insult.
eg. That pussyhole did not remember to pick me up last night
pussyhole by punsy April 3, 2007

massholes 

People who come from/born in mass.
Generaly called 'massholes' due to how they drive on the highway and in citys
That car just hit scotty's 90 year old grandmother and didn't even stop. The massholes!
massholes by Christofer December 12, 2006
1) A person from Massachusetts
2) A terrible driver
3) All of the above
Drive through Boston, and the meaning of the word will become clear.
WHAT THE HELL that fucking masshole just cut me off!
masshole by Joel June 10, 2004

Pussyhole 

A Jarod that complains all the time and bitches like a woman.
He ran his mouth like a pussyhole because he was early to the job.
Pussyhole by Uadouche January 25, 2019
An adjective, typically used to describe a rude or discourteous person, most commonly in conjunction with the operation of a motor vehicle.

Examples of such behavior might include, but should not be limited to: tailgating, lane drifting, weaving, random stopping, randomly leaving a turn signal on, not using a turn signal to indicate a turn, inability to merge, inability to yield, inability to observe posted signs for anything, or any combination of these.
Just ride on the Mass Pike. Multiple examples will immediately come to mind.
Masshole by Andrew February 9, 2004

Mursehole 

The combination of Masshole (Mass resident) and Murse (male nurse). This word is widely used in the Tri-State area due to the heavy influx of Male nurses from Massachusetts. Massachusetts requires that nurses have their BSN, thus sending Associate Degree male nurses our way. These Murseholes tend to hold themselves in a higher regard than the rest of the nursing population; without cause or true reasoning. Many of these Murseholes tend to job hop, i.e. work at just about every hospital imaginable.
Nurse A: "That Mursehole sure didn't last very long"
Nurse B: "Well what did you expect, Murseholes are not very well received by patients and staff alike"
Mursehole by Silly RN April 22, 2008