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When the Adderall or Vyvanse are seriously hitting; the climax of the high.
"Man, I just had a coffee and an adderall...I'm at peak tweak right now."
by swaitt28 December 10, 2019
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Langford Tweak

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If you live in Langford and occasionally smoke meth and bother innocent bystanders
Oh look it’s Josh Worthy! A langford tweak! hopefully he doesn’t tweak out and rob me and stomp me out!
by methhoots123 June 15, 2022
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Teasing Tweak

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A girl that goes aroung "Talkin" to everybody, kissin everybody. She Doesnt fuck them she leads them on with all the sexual attention, like the kissin the lickin wisperin in the ear.
One Day Yur Kissin One Boy
The Next Day Yur Kissin Another
Then Yur kiss sum different boy in school
Then Go Home And Kiss The First Boy Yu Kissed. #Teasing Tweak

Or .... Goin Wit The Whole Team Jst No Sex Involed

Boy: Ayee Bro Yu See Tht Bitch
Bro: Yea Thts The Jawn I Go Wit
Boy: Dont Talk To Her She A Fuckin Teasin Tweak
Bro: How
Boy: She Been Around The Whole Fuckin Team, Givin Us All The Signs Of Sex. And She Aint Fuck Nobody!
Bro: Damn, She Gotta Go !
by TweeterTweet December 21, 2010
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Term used by D.C. local children to describe weed... these kids most likely smoke weed themselves and will ask to smoke ur weed... be aware that they may try to rob you or scare you with stating they have a gun after smoking ur weed.
Ayo ya'll.. they got dat tweak over here, they smokin tweak... Can I Hit?
by IDEALS May 31, 2007
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Tweek Tweak

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Tweek Tweak is an south park character.He will be my future husband.Tweek Tweak is a kawaii boi who fell in love with coffee With Meth.Also,Tweek has a "friend" call "Craig Tucker"who call Tweek "Honey" and "babe".And Tweek is a sexy babe too<3,i want kick his ass,don't kick the baby.
Anyways,i want to try Tweek bro's coffee which with Meth.
And last,"too much pressure"
And Tweek sexy<3
Tweek Tweak:"too much pressure" he sexy
by Tweektoomuchpressure May 22, 2021
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When a tweaker has been on such a long binge that they have no concept of time and believe they're previous actions happened only an hour or day ago when it was actually a week ago.
No way man, that wasn't yesterday when that happened, it was last tweak.
by 1 Antinome June 30, 2017
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cracker tweak

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Cracker tweak is basically the bath salts of the Midwest. Mostly white people take it so that’s why it isn’t just called tweak
Homeless person: “Hey y’all got some of that cracker tweak?”
Jonny: “No sir, i May be a cracker but I’m not a tweaker.”
by tHINGYsPLASH August 19, 2019
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