Duff

D.u.f.f- Dumb Ugly Fat Fuck, only used with girls but can be used with guys if necessary.

That girl at that lunch table eating jello is a fucking duff

by Kevin Derr May 4, 2007

Duff

The cannabis material that is left after vaporization (which it is still good for cooking).

I made awesome brownies with the duff from last weeks party!

by CaraBeantown January 5, 2014

duff

Dumb Ugly Fat Friend. Every hot girl has at least one. If, in the case, that a hot girl has other hot girl friends, then they all have at least one mutual duff. Hot girls chill with them to usually make themselves seem better.

Yo dawg, we gotta get this DUFF away asap.

by the_realest_MI March 4, 2011

Duff

Designated Unpopular Fat Friend. A fat person,usually a female who is obsessed with a country boy,his friends,his momma,sister,truck and dog.

Girl: Where did all my ice cream go?
Boy: The duff must have ate it.

by brotherman94 February 8, 2012

Duff

Dumb Ulgy Fat Friend. The one friend that people only talk to to find out info on their hot friends

I want to find more stuff out about Nikki. I'm going to ask her Duff

by thatonegirl3000 March 8, 2015

duff

consumimg cannabis sativa by means of smoke.

wrestling is coming up soon it's about time to duff

by d-boy April 30, 2003

Duff

to spill something on your clothes.

I duffed my coffee this morning during the commute.

by Argh Dammit September 25, 2005