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Used to say hello to any thing (person, dog, cat)
When you go over to your freinds house you say. Hey what's up skin.
by Arnold palmer 1 October 10, 2018
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Telling someone you understand what they are talking about.
George: After you wash the car you need to feed the dog and take out the cat.

Bill: Ok George, I'm picking up what you're putting down!
by PirateEyeZ May 21, 2008
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what's up now

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A rhetorical question used when one is in a difficult predicament and the circumstances suddenly change in his/her favor, such as when the person in trouble pulls out a gat or when his/her posse shows up ready to whoop some ass. Often followed by "bitch" or "punk" to further assert dominance.
Barack Obama: "Now that I've won the Iowa caucus, I have the Democratic nomination in the bag. The New Hampshire primary is going to be a walk in the park."
(Hillary Clinton wins New Hampshire primary)
Hillary Clinton: "Hell yeah! What's up now, bitch???"
(Barack Obama wins the Democratic nomination)
Hillary Clinton (obviously insincerely): "Congratulations, Senator Obama. I am so happy for you. The American people definitely made the right choice."
Barack Obama: "Three words, Senator Clinton: WHAT'S UP NOW?!?!?!"
by Nicholas D February 26, 2009
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A sarcastic response to a persons bad attitude
Alice: Oh wow! Did you hear that cardinal?

Jack: Yeah, annoying little prick.

Alice: What crawled up your ass and died?
by OrvilleFan December 18, 2019
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A common slang way african american friends say hello to one each other.
"Yo, what's up my nigger."

(Translated)

"Hello, how are you my african american friend.?"
by xxlivefastttxx February 12, 2009
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what’s up bitches

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Term of endearment among a group of friends. Used typically to say hello to a group of friends. Other forms are “Whatup bitches”.
by Digitaldeathalone May 6, 2018
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what's up ladies??

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Question a blind man asks while walking by the fish market.
Blind man: Hey "what's up ladies??"
Foreman: you retard, that's Tha local market we are working.
Blind man: Sorry bitches!. my eyes betray me but the nose knows you filthy whore!
by sciflyer.25 November 30, 2016
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