Pharmaceuticals that cause people to be bitchy, arrogant, snobbish, stuck-up and just plain rude. This may be either an intended effect of a medication or a side effect.
What the hell is the problem with that blonde? Is this how she usually behaves or is she on some kind of barbitchuate? Her doctor needs to stop prescribing those to her. She's intolerable to be around.
A sedative-typedrugdat makes you really grumpy prior to falling asleep.
I already have a tendency to be ill-tempered whenever I'm not at my best, so I don't wanna make things even worse by going on barbitchurates to help me get some shut-eye --- I'll just tell Alexa to play soft music for an hour so dat I can doze off naturally!