The female noun/verb combo of the very popular "cockblock" or "cock block". A muffcuff occurs when a female is twarted from her goals or desires by someone else. The person doing the thwarting (aka the muffcuffer) could be a person, place or thing, or even a vague, abstract concept.
omg that ho totally just muffcuffed me when she showed her slutty cleavage to the bartender.
An argument between two people of the female gender which escalates into a fight. These arguments are particularly nasty and may end in hair pulling, gouging, scratching and screaming incoherent words.