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The set up to a joke; when one asks what it is, it sounds like, "What's Up Dog" to which you reply, "Not Much, You?" Or something like that. The joke became wildly popular due to it's use in a 2006 episode of The Office called, "The Secret".
Hey, did you hear about that updog poisoning in New Mexico?

What's Updog?

Not much, you?
Updog by X040KL1M December 17, 2021
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When you ask someone about something called "Updog" that sounds like a computer virus and when they ask you just answer with "Nothing much, wbu?"
Me:Ayo have you heard about the New Updog virus?

Retarded fuck: What's Updog?

Me: Nothing much bro, wbu?
Updog by 12321312323434 February 1, 2022
Nothing much, just playing video games.
"What's updog?"
"Nothing much, just playing video games."
Updog by Kamil118 August 8, 2022
updog; a derogatory term for a homosexual person
person: yo, ur so updog
9 yr boy: whats an updog
person: FAGGO-
news reporter "9 yr boy kills himself after homophobic bullying"
updog by anonymous October 24, 2022
updog; a derogatory term for a gay person
person: bor, ur so updog
9 year old kid: whats updog?
person: FAGGO-
news reporter: '9 yr boy kills himself after homophobic bullying'
updog by anonymous October 24, 2022
updog is the amount of death of dogs that happen each 15 days, if the updog is more then 50 % you should run fast.
hey the updog is high, we need to move out
updog by the only joe papa November 14, 2022
Asking your foreign gf to put her hand up your ass.
"Can you pass me the updog?"
"You want me to put my hand in your ass?"
Updog by Bobby Lee Buckets January 11, 2023