This word has no definition in any known language. It is soley used in the english language as a set up for a joke, relating to the common phrase "what's up?" And the referal to a person as "dog".
Person 1: "Ew, it smells like updog in here."
Person 2: "What?"
Person 1: "You know, updog."
Person 2: "What's updog?"
Person 1: "Not much what's up with you"
Person 2: *punches Person 1 for making such a terrible joke*
by Nothing is left but this April 3, 2018
A joke that was good the first time you heard it, but then got shitty after the seventh time you heard it.
“Dude, it smells like updog in here.”

“What’s updog?”

“Nothing much how about you?( ͡° ͜ʖ ͡°)”

“WHAT’S UPDOG? YOU SON OF A FISH! TELL ME!”
by What_A_Dayyyy July 17, 2018
UPDOG (Ultimate Paralyzation of Damaged Organ Genetics) is a process in the BOFA (Body Oscillation / Fatal Area) in which DNA is modified into having LIGMA symptoms in the genetics. This is only a stage 1 on the BOFA power level, however a person will suffer from intense addiction to Fortnite, get free Xbox Live or PlayStation Plus, and the ability to gain a free copy of the Save The World mode at birth. Though most of these symptoms sound positive, one negative symptoms will occur, a UPDOG victim will forever stay a virgin. It is unable to change that fact. Some popular examples of people with UPDOG include: TSM_Myth, every 12 year old, Ninja, Runescape players, and most likely you.
Person 1: Updog
Person 2: What’s Updog
Person 1: It’s when you get a free stuff from Epic for having special genes
Person 2: At least I’m not a virgin
by Heckin’HeckHeckers August 10, 2018
When one exclaims that it smells like updog he is attempting to humiliate others in the room who are formerly not aware of the joke by making them say “What’s up dog?”
Person #1: wow it really smells like updog in here
Person #2 what’s up dog?
Whole church: ahahahahahah
by Dwayne the glock Johnson February 7, 2019
Updog is part of a joke. Pretty easy to get. Hilarious if person does't get it.
Bob: Hey you smell like updog.
Victim What's updog?
Bob: Oh nothing much.
Victim: What's up dog?
Bob: I told ya, nothin' much.
Victim: WHAT'S UP DO- OH I get it now......
by I smell like updog. August 12, 2011
A dog superhero whose superpower is trolling people with henways. Oh, and he tackles criminals like Joe and Candice I suppose.
Guy: How are you gonna rob me with Updog behind you?
Robber: What's updog?
Updog: Nothing much, what's up with you, dog?
Robber: crap
by E hates Q September 20, 2021
A chemical residue typically left from common biochemical bases, due to the releases of dead cells reacting with the surrounding air.
Known especially for its repugnant smell, often used as an exaggeration to describe a bad smell.
It smells like Updog in here.
by alsjkdf March 21, 2019