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setting yourself up 

John:This is so hard, that's what she said.
Brian:Dude, you're setting yourself up.

setting up a new network 

When your friend makes up an excuse to skip game night but is actually at home practicing shibari with their partner.
Man 1: Yo bro! You doing Family Game Night?
Man 2: Sorry Homeslice, setting up a new network tonight.

setting the table

When someone, usually in a public restroom, flushes the toilet before they sit down to use it. (Term can be used whether or not something was actually in the toilet that merited flushing.)
As I was contemplating life in the Wal-Mart bathroom a man walked into the stall next to mine, setting the table before he sat down.
setting the table by jimmywho723a January 25, 2009

setting up shop 

The act of preparing oneself for a session of sex with oneself (jerking off).
I forgot my backpack and when I ran back in to my apartment I caught my roommate setting up shop.
setting up shop by jeff74033 April 14, 2008

Setting Sail

When a ship between two characters becomes popular
The fact that minion ships are setting sail makes me disappointed in humanity.
Setting Sail by definedefinition November 12, 2015

Setting Up 

A term most used in video games, such as Gears of War. The term is most frequently used when someone records a "montage."
Gamer : "Dude! That quad was amazing!"
Other Gamer : "He was most likely Setting Up because they were standing still."
Setting Up by hobbesfx July 11, 2010