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Like a Hangover but when you play videogames for too long and develop a headache and a senstivity to bright lights and loud noises.
I played video games with Renx all night and woke up with a horrible game-over.
Game-over by originalrenx December 6, 2009

Gayed over

1. Used to describe anything that is not working or did not go your way.

2. Aeguvas
Gayed over by Maxaris October 22, 2003

game over 

When you beat someone in any type of situation. Also an exclaimation when you beat the shit out of some asshole. Or when a situation is just outta hand and you don't want to deal with it anymore.
Give it up bitch, game over.
GAME OVER MOTHER FUCKER!
This is game over for me, I'm out.
game over by grrrinator October 27, 2004

game over 

Phrase used to describe one who has consumed far too much liquor and is therefore reduced to a drooling, snoring, unconcious lump who may or may not end up vomiting on themselves or other people later on in the evening. May sometimes lead to boot and rally, pissing in the fridge, or other drunken acts which will undoubtedly not be remembered in the morning. See ptfo. This is the most opportune time to attempt such daring feats such as teabagging, giving a flying squirrel or other humiliating acts.
Dude, check nick out, Game over.
Woah, did nick just boot-n-rally? i thought it was game over! add another tick to the boot-n-rally tally.
game over by Ry-Lo October 1, 2007

Game Over 

1.Something that is Over.
2. A situration that is lost.
3.Nothing left to do.
Man! I lost the match Game Over.
His wife just caught him cheatin."Game Over"
Game Over by DE-BO July 5, 2004

Game over. 

When you finally end it completely... you’re a swallower & even you won’t swallow anymore of their bullshit.
Ohhh... so you like to play games...?

Lol... sorry baby, I was the real deal... don’t wanna play that kinda game . game over.
Game over. by java804 May 12, 2018