Duff Hunter 

Hunter of the DUFF (Designated Ugly Fat Friend), not to be confused with the Milf Hunter. The Duff Hunter is solely after big game and nothing else, like a cheetah in the Serengeti taking down a wounded gazelle.

The Duff Hunter claims another victim and slays a fatty.

Duff Hunter by The Duff Hunter February 20, 2015

Duff mckagan 

The bassist for guns n' roses for all of their albums except chinese democracy. He is now with Slash in Velvet Revolver. He was a good bassist, and is also a realy nice guy. He now has had to give up the rock star lifestyle since he's married with 2 kids, but he still rocks when he's playing music. never actualy was kicked out of guns n roses- he and Slash, the only original members left, kicked Axl Rose and all the replacement members out in '98. Axl then sued them for the rights to the name, won, and Duff and Slash formed Velvet Revolver. Like the other gunners, duff had trouble with drugs and booze. he now has quit drinking, after his pancreas burst and he learned that any more alchohol would kill him. He's not much of a partier any more, but he's still a realy cool guy.

Duff McKagan is the man. 'Nuff said.

Duff mckagan by king of canada September 9, 2006

duff beer 

A brand of beer drank by Homer Simpson and his friends in popular Television show "The Simpsons". It is the only drink that Moe Syzlack stocks at his tavern, Moe's Tavern.

"Hey Moe, Gimme a Duff Beer, please."- Homer Simpson

duff beer by Tuddy September 10, 2007

duff beer 

phoney beer brand ala the simpsons

duff beer by mertyl June 6, 2003

DUFF cocktail 

a drink spiked with roofies and viagra used by the DUFF(designated ugly fat friend) in order to get laid.

"dude dont drink that its a DUFF cocktail." "i woke up with a headace and a raging boner next to a WHALE, It must have been the Duff Cocktail."

DUFF cocktail by [THE]fixer5588 March 15, 2010

Duff (D.U.F.F.) 

abv. for Designated Ugly Fat Friend; Term men use to describe a fatter, less attractive friend, a woman brings with her to a party or social gathering to make herself look better by comparison. In some cases the more attractive woman will not "put out" for any male, unless one of his friends "takes one for the team" and "hits" the Duff.

C'mon take one for the team and hit that Duff (D.U.F.F.), I'll buy you lunch tomorrow!

Duff (D.U.F.F.) by Dr. Slappy McGee III Esq. March 19, 2006

duff up 

to beat someone up and win

i'm gonna duff you up!

duff up by frank April 23, 2003