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don't have a cow 

See have a cow. "Don't have a cow" is a trademark expression for the TV series' favorite son, Bart Simpson. Bart is the typical problem child who is always testing the authority figures in his life. In contrast is the good child, Lisa Simpson, who is never a challenge to her elders -- and often fades into the woodwork because of it.
Lisa started to freak out when Bart took the bottle of rum from the cabinet, poured one cup out, then filled the bottle back up with water. Bart socked Lisa in the arm and said, "Don't have a cow!"
don't have a cow by MsLi January 29, 2006

Don't have a cow man 

One of Bart Simpson's telltale catchphrases
"don't have a cow man" said Bart after he burnt down Skinner's house

to have a cow

an alteration of the term ' to have kittens' to strongly overreact to a situation.
I scratched my Dad's car and he had a cow -now I am not allowed to borrow it for a year!
to have a cow by Intensity January 9, 2005

I'm gonna have a cow 

A term used to express excitement and anger and about any emotion imaginable. But be careful, people might assume you are literally giving birth to cows. If you choose to play along with this childish idea, make disturbing groans while squeezing your buttcheeks together. And people may ask you where you keep your cows. Tell them that you keep them in a pin behind your house!
(Accidentally drops phone and cracks screen)
Suzzy: Oh my goodness, I'm gonna have a cow!
(Friends throw a surprise birthday party)
Friends: SURPRISE!

Herald: AH! I'm gonna have a cow!
(Also consider... Trips and falls on school stairs in front of hot seniors)
Tina: About 24 cows just escaped my pin... ;(

Don’t have a cow, man! 

An admonition spoken to a male seahorse who is concerned that he's gonna give birth to sea CATTLE instead of sea HORSES.
Most creatures reproduce though the female, with the male providing fertilization of her eggs while their still "in her oven". But male seahorses do somewhat the opposite --- the female deposits her sterile eggs into the male's sperm-filled egg-pouch, where the eggs are fertilized and remain till they hatch. Once in a while, though, something goes wrong with the process, and the male becomes concerned that his eggs are turning into aquatic cattle instead of horses, prompting others in his clan to anxiously admonish, "Don’t have a cow, man!"