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Aspirin between the knees 

Implies that if a woman were to suspend an aspirin between her knees, she would be unable to spread her legs without dropping the aspirin, thus, by keeping the aspirin suspended between her knees, she would be unable to engage in activities deemed sinful by crazy out-of-touch right wing nut jobs who wish to impose their religious will on the American public
Person 1:

"Hey! Did you see that Rick Santorum supporter Foster Friess on TV the other day? That nut job actually suggested that women should suspend an aspirin between the knees and use that as contraception!"

Person 2:
"Man, that guy is out of touch! I guess we can thank right wing nutters like those guys for paving the way to Obama's second term..."
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Aspirin between my knees

To make some phenomenal gaffe or faux pas, similar to putting your foot in your mouth.
Man, I really put the aspirin between my knees yesterday. I told Jen that her new dress made her look fat.

Rich Mans Aspirin 

Noun. Top Quality Cocaine.
So named because of the analgesic (pain relieving) effects of cocaine, and how it can be used excessively, despite the expense, by the wealthy.
Mr. Richworthton is complaining of a migraine, please take this $1000 and get him some Rich Mans Aspirin from his dealer.
Rich Mans Aspirin by GlamKitten November 8, 2011

.45 caliber aspirin

To shoot ones' self in the head with a .45 caliber bullet.
I'd take a .45 caliber aspirin and die a sad person before taking a class with that professor again.

Children's Aspirin 

1 part Captain Morgan, 1 part orange juice. Also known as a "rum screwdriver" or a "hammer."
"Oi! Bartender! Fetch me a Children's Aspirin!"
Children's Aspirin by James Rodesiler September 25, 2007

Black Aspirin 

A pseudonym given to a certain dark, sugary soft drink that shall remain nameless. Believed to have an re-energising effect on those suffering symptoms of the night before.
Whoa man, i had a bender last night. My head is throbbing, can you duck down to the shops and fetch me a bottle of Black Aspirin? I'll pay you back - i swear!
Black Aspirin by Benebrius April 10, 2010

half sucked aspirin 

The description of a person's face which resembles a partially dissolved aspirin tablet, in that it is pockmarked and lumpy.
"Oh did you see Cameron Diaz without make-up? she's got a head like a half sucked aspirin!"