Pukeanuke Share definition Flag An uncontollable case of vomiting that gives no warning and is accompanied by an extremely loud purging sound, simlilar to an explosion. I could tell Billy had had too much to drink when he pukeanuked all over our pizza. Pukeanuke by Jimmythegimp January 17, 2011 0 0 Get merch Get the Pukeanuke mug. Buy Now — $32.95 See more merch