22 Share definition Flag The number of love. When two people fall in love, the number 22 will follow you. If you see a 22, that means that the person you are in love with is thinking about you. Listening to Love Story at 12:22 in the afternoon. 22 by 122206 January 18, 2010 0 0 Get merch Get the 22 mug. Buy Now — $32.95 See more merch