1) to get absolutely off your head, usually on alcohol and
drugs but can be used to
mean just get pissed.
2) to be
confused.
Ex. 1)
P1: this weekend is gonna be
deadly!!
P2: i know i havent been madded in ages.
Ex 2)
david blaine: and
now i will eat my own head twaa...
*eats his head*
P1: wow!! how the fuck did he do that????
P2: i dont know, that has just
totally madded my head