Man, yo! Share definition Flag A term used when something is so suprisingly ridiculous, you cannot find the words to explain your utter speechlessness. Cole: "That bitch got all that orange make-up shit on!"Van: "Man, yo!" Man, yo! by Painkiller625 August 1, 2011 0 0 Get merch Get the Man, yo! mug. Buy Now ā $32.95 See more merch