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The social, legal, or institutional discrimination against individuals who are mentally ill/neurodivergent, or who may be considered "not sane" by society's standards. This can often cross over into ableism.

The term sanism was originally coined by Morton Birnbaum.

Some oppressive terms that reinforce sanist stereotypes: crazy, insane, psycho, retarded, dumb, mad house, mental case; misuse of medical terms such as OCD, bipolar, schizophrenic, autistic, etc.
Jesse: I can't attend college in person due to my social anxiety and depression, so I take my courses online.
May: That's ridiculous. Everyone dislikes going to school. Just suck it up.
Jesse: That's sanism.
sanism by ThawahCawwey September 10, 2016
Related Words
Someone's quality of doing something by themselves
You have no sylism in you, you just wait for someone to do something for you.
Sylism by Taveouster March 8, 2018
The way a dumb emo with a bad haircut spells sinister.
He needed to save ink to put around his eyes cause his mum confiscated his mascara, so he spelt sinister with two less letters. WTF is a synista?
synista by Seals October 17, 2006
Wet, sticky mixture of rain and snow. It sticks to everything like, well, you know.
There's a nasty layer of snism all over the from yard. This ought to be fun to clean up.
snism by CDubb November 23, 2013

Synister Weasel 

A Synister Weasel is promiscuous female, one who may deceptively act innocent whilst cheating on her man.
"Yo, just brapped out some guy in Gedzville tossing ma' girls salad!"

"man, that gash is a synister weasel, bre!"
Synister Weasel by MC Scratch January 1, 2009
The belief that the world is a load of bollocks and the wish to go live in a log cabin in sum random place with a racoon and jen.
"Slater and Jen are the co-founders of syncism"
Syncism by mark slater January 26, 2006