23 definitions by reptiles
by reptiles October 4, 2002
by reptiles October 4, 2002
As a rule of thumb, it is profoundly unwise to take crack-cocaine. The brain has evolved a truly vicious set of negative feedback mechanisms. Their functional effect is to stop us from being truly happy for long. Nature is cruelly parsimonious with pleasure. The initial short-lived euphoria of a reinforcer as powerful as crack will be followed by a "crash". This involves anxiety, depression, irritability, extreme fatigue and possibly paranoia. Physical health may deteriorate. An intense craving for more cocaine develops. In heavy users, stereotyped compulsive and repetitive patterns of behaviour may occur. So may tactile hallucinations of insects crawling underneath the skin ("formication"). Severe depressive conditions may follow; agitated delirium; and also a syndrome sometimes known as toxic paranoid psychosis. The neural aftereffects of chronic cocaine use include changes in monoamine metabolites and uptake transporters. There is down-regulation of dopamine D2 receptors to compensate for their drug-induced overstimulation. Thus the brain's capacity to experience pleasure is diminished.
He was a normal guy until he started smoking crack, now he is a hustler that sucks dick for $5 to buy another rock.
by reptiles October 4, 2002
1. n. generally refers to the fruiting bodies of the fungus in the genus psilocybe. 2. any non-poisonous mushroom with visionary or entheogenic properties.
by reptiles October 4, 2002
by reptiles October 4, 2002
Methylenedioxy-n-methylamphetamine MDMA is a 'psychedelic amphetamine' that has gained popularity over the past 20 years because of its ability to produce strong feelings of comfort, empathy, and connection to others. It most frequently comes in tablet form, although it is occasionally sold in capsules or as powder. It is most frequently used orally and rarely snorted. MDMA use is closely tied to the underground rave (and dance club) scene throughout the world, but has also been widely used by therapists as an adjunct to psychotherapy.
by reptiles October 4, 2002