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u2u commonly means "user to user" - this is usually referring to cyber sex on the internet, whether it be on msn, aim, cybercam, etc.
"Hey I'm Audrey. I'm seventeen, tan, blonde, green eyes. Anyone wanna u2u?"
"Ohh yes baby I wanna stick my thick hard cock deep in your wet pussy."
"Fuck yes! Do you have msn?"
by November 21, 2007
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