(or tweek) To slightly adjust one's computer in order to increase it's speed. Often associated with overclocking.
I've loved to tweak the shit out of everything ever since I started messing around with computers.
by Zamfir June 18, 2004
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Verb. To deliberately provoke, to push someone's buttons.
"So I said, 'how many feminists does it take to change a light bulb?' She said, 'How many?' I said, 'Three. One to take out the old bulb, one to put in the new one, and one to suck my dick."

"Did you do that just to tweak her?"
by Danny Delinquent December 04, 2003
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1. To prefect something
2. Used to replace cool or related words in a sentence as an adjective

1. I totally tweaked my kickfilp today
2. Man thats party was tweak as !
by Ev-Dawg October 02, 2007
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(Verb) To experience the speedy, lifted, euphoric effects of the drug Adderall or generic Adderall. NOT to be confused with the "half-tweaked" or "zombie" state experienced by those who take it too often (marked by indifference, and a strange respiratory effect in some that produces a "Hkkekkuuhehkk" sound upon trying to sleep).
"Dude, I just wrote five pages in a half hour."
"Man, you're tweaking!"
"This is awesome!!"
"Don't turn into a zombie - you'd piss everyone off and make weird 'Hkk' noises.. like someone we know!"
"Yeah, I love tweaking, not half-tweaking!"
by KingOfOranges June 02, 2013
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Someone who overly acts weird, reacts in a weird way, or acts unnormal and squarish.
When a teen acts too excited in class and starts tweaking out.
by magsoldier15 January 20, 2011
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