when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
When someone calls you after something that affects them, generally in a bad way, just to talk on their way home.
It is done for the companionship of being walked home when the person can't physically be there.
"thanks for talking me home from the pub last night, I was too drunk to get home on my own"
"I was talked home by my friend last night when I couldn't make it alone" "that was nice of them"