teeth on edge 

The feeling of extreme irritation or annoyance resulting from an individuals behavior, or an unpleasant stimuli (ie. nails on a chalkboard)

Phrase is derived from the tingling/painful sensation felt in one's teeth after eating something cold, or biting into something hard.

That lady's incessant hyena pitched laugh is really setting my teeth on edge.

teeth on edge by Hubbuh January 25, 2021