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A brain disorder that occurs when a person is high which makes them do outrageous things they wouldn't normally do and/or to act completely insane.
"Why is Gracie dancing on that table naked grinding up against four naked elderly men?"

"Yo she is suffering from synthesitis"
by Sarah Elaine April 27, 2005
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Jul 11 Word of the Day
selfish idiots in my neighborhood who think that they don't need to wear a mask because the rest of us do
A maskhole jogged right past me in the park today
by Bethinslope May 11, 2020
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