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Usually a kissass, a smart number 2 in charge, or someone who manipulates people with power to further his own agendas.
"Watch what you say around him, he's the Warden's shady Skizzo"
Skizzo by Skizz0 February 27, 2022
Related Words
a skank-ass hizzo
skizzo by Anonymous July 2, 2003
Someone who quite literally lost their mind, in a calm way.
They constantly browse memes that arent even funny, but yet show a sign for help.

They wont talk to you, dont even try
Normal person: Hey you wanna go hang out?

skizzo person: no im busy sorry (proceeds to cry himself to sleep later on)
skizzo by skunkkk May 25, 2022

Flip skizzo 

A girl that acts somewhat slutty, but isnt a real slut. She is also very flirty, flipping back and forth from guy to guy, flirty with each one.

Also can be shortenend to just "skizzo"
"Hey bro what up with felicia?
" oh she just a flip skizzo, that bitch dont put out . Find someone else thatll let you pork 'em.
Flip skizzo by CkinleyB October 3, 2016

Dirty skizzo 

when someone has a big dick and is a freak but acts innocent
that guy over there is being such a dirty skizzo
Dirty skizzo by swindelkins May 17, 2020
When a male ejaculates with so much force that his semen is projected down the esophagus of the person performing oral sex.
“I sucked it so good that his cum slizzo’d down my throat.”
“You look so damn sexy, baby. I could just slizzo you right now.”
slizzo by slizz ball November 29, 2021