shysol Share definition Flag when someone at works takes a shit then tries to coverit up with lysol. Man,someone came and took a shit in our bathroom, sprayed the whole can of lyson and now it smells like shysol in there. shysol by Humbataz January 29, 2009 0 0 Get merch Get the shysol mug. Buy Now — $32.95 See more merch