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It's a word that's used with Italians or Italian Americans when informally, but friendly, adressing one another. It means "brother" or "fellow countryman". Shortened from paisano, and is sometimes spelled paesan.
"Hey, paisan! How's the veal parmigiana?"
"Delicious, best in the city!"
paisan by Alumita November 11, 2005
Related Words
n. means countryman or brother in Italian. The equivilent of "homie" to Italians and Italian-Americans.
Usually spelled paesano.
Sometimes shortened to paesan or paisan
Yo, howyoudoing, paisano?
paisano by Jam Master J April 14, 2005
Maria has a fat paishasha
Paishasha by xjoaosantos March 16, 2019
Juan is very , paisa, he blasts Mexican music in his pick up truck
Paisa by panchitof1 October 19, 2017

Paisano/Paisan

Paisano/Paesano/Paisan -Italian(n) referring to another Italian(n)who is from the same village or area/region in Italy.
Countryman
Alfredo is a Paisano/Paisan also from (name of ancestral homeland-village) or region of Italy; as in Marchegiano (a person from the region of Le Marche).

paisa fever 

when a person is attracted to mexicans, mexican-american, or the likeness of mexicans both physically and sexually
Oh my god, i think that mexicano is like so totally hot!
you have Paisa Fever
paisa fever by Bonito October 29, 2007