It's a word that's used with Italians or Italian Americans when informally, but friendly, adressing one another. It means "brother" or "fellow countryman". Shortened from paisano, and is sometimes spelled paesan.
"Hey, paisan! How's the veal parmigiana?"
"Delicious, best in the city!"
by Alumita November 11, 2005
Sicilian Italian word for fellow countryman
hello paisan, how may I help you?
by Sexydimma November 7, 2019
Italian American Vernacular English: a nonstandard form of Italian English characteristically spoken by Italian Americans in the United States.
"Yo Vinny, fogettabout clippin' Johnnie...he's a made man. Friggin' goomba whacked Joey-Lips because he's nothing more than a gavone."

Paisanics to English Translation...

"Vincent, you shouldn't consider murdering Jonathan because he's untouchable. My friend there killed Joseph (who likes to talk a lot) because he was an embarrassment to himself."
by Dan-Fu March 12, 2009
Paisan/Paisno- Someone if Italian descent that understands the significance of simply being Italian. Their fainikts consist of absurd shouts of loud individuals who talk way to load. This can be use as a greeting.
Joe: “ayyy paisano what’s up?”
Tony” tell Vinny I said Ciao, that man is my paisano”
Michael”have you tried Angela’s sauce?”
Erminllindo: “that guy makes a nice sauce. What a paisan
by Thereistruthindrugs February 22, 2018
Paisano/Paesano/Paisan -Italian(n) referring to another Italian(n)who is from the same village or area/region in Italy.
Countryman
Alfredo is a Paisano/Paisan also from (name of ancestral homeland-village) or region of Italy; as in Marchegiano (a person from the region of Le Marche).
by mhaydenangellotti April 18, 2018