This idiom has several meanings:

1. over the most difficult part of something; past a midpoint of something, but not in relation to a particular age.

2. intoxicated on a drug(s).

3. an album by the band called the Kelly Family in 2004.
Things will be easy from now on. When you get over the hump, life is so much better.

Make me over the hump.

Benny is over the hump now. He is way stoned. This stuff makes you sick at first. Then suddenly you are over the hump and floating.
by Krumpsley January 20, 2012
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