Mud Puppy Share definition Flag A derogatory term used to describe the mixed race offspring of a multi-racial couple. "Here comes another fat ugly white chick and her 5 ft. 4 inch tall wetback husband. Oh how nice, they even have a mud puppy." Mud Puppy by zombiemaster666 July 13, 2009 0 0 Get merch Get the Mud Puppy mug. Buy Now — $32.95 See more merch