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The Last of the Mohicans 

That last piece of poop that just refuses to leave your anus, constantly making you late for important events.
Sorry Boss, I'd of gotten to the meeting sooner but The Last of the Mohicans just wouldn't let go.

Last of the Mohicans 

The last cigarette/joint in a pack. Typically used to decide whether to smoke it or leave it for some more time
Thats the last of the mohicans, but we can get more if you are really that desperate

Last of the Mohicans 

When you are fucking a girl on chemo from behind and her pony tail comes off in your hand.
She was pretty sick but I still fucked her hard. I ended up doing a Last of the Mohicans on her as I came.