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1. something that crosses two or more states
2. the name of a few highways in the U.S.
We are arriving at Interstate 210, please be ready to unbuckle. This is a bus rest station and this is your chance to go to the restroom, or buy something to eat.
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by 25IMF June 26, 2019
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2
n. American amateur raceway. Frequently becomes a facilitator for natural selection. Unfortunately, Interstate "natural selections" often involve normal drivers who happen to be at the wrong place at the wrong time.
Syn: "Darwin's Little Helper"
Wow, those teens flipped that car while going 90 on the Interstate and weren't wearing seat belts. I guess they won't be breeding.
by ScabNainz January 31, 2005
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