I live in the southeast US. I first started hearing "flustrated" by local speakers a few years ago. It was apparent that the speakers were not using this for comic effect; the speakers were quite angry at the time.

I don't think that it's a combination of flustered and frustrated...just a variant pronounciation of "frustrated". If you look at the examples used by the other contributors on this site, I think that they illustrate the use of this term as "frustrated".

A few weeks ago, no one had “cheugy” in their vocabulary . Now everything is saturated with the word. It’s in our heads. It’s in our homes. Everyone is asking: “Am I cheugy? Am I a basic ass bitch? Am I GUILTY of being cheugy?”

The proliferation of cheugy in the mainstream discourse can only be attributed to one source: mental terror. It’s an orchestrated psychological trap to make you question your tastes and interests in the eyes of others.

You are not a cheug. YOU’RE PERFECT!!!!

It is very suspicious that the cheugy mascot is a Minion, a literal cyclops, a deformed
yellow panopticon in overalls ... do not let the all-seeing eye to control you. Be vigilant. Resist cheugy psyops.

Flustration is wrongly spelled Frustration.

This mistake possible came from the attempt to join words frustrated and flustered which is senseless.

See other translations.
(Note: they are wrong.)

1) To become frustrated and flustered at the same time cauz you cant get what you want 2) to be like Neil

Flustered & Frustrated combined into the one word to describe a combined feeling of both emotions.

To be frustrated and flustered at the same time.

A made up word apparently by southerners, which combines "frustrated" with "flustered"