cottonball Share definition Flag when a guy wraps is balls in cotton so they are sensitive and then puts them in a girls mouth cesco: so did you give that slut a cottonball last night?hayden: you know it bro! it was so sick! cottonball by theking0123456789 September 12, 2009 0 0 Get merch Get the cottonball mug. Buy Now — $32.95 See more merch