A form of diarrhea caused by bacteria Clostridium difficil, that lives in poop.
Aaron can't go out tonight. He's got toxic mega-colon.
by moneypenny07 March 20, 2009
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This phrase is mostly used when you want to say something that makes absolutely no sense. but its funny.
Fagget 1" hey get outta here bitch!"

Fagget 2 " hey how bout you tickle my colon!'
by GG_delux_yg4hunnid April 20, 2016
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Refers to a rip-roaring case of "liquid farts" --- not just a case of mundane "trots", but a full-blown bout of "galloping diarrhea", like you're actually urinating out of your large intestine.
My country-cousin friends graciously invited me to help myself to the leftovers in their fridge while I was visiting them for a couple weeks this past July. That was all great, except that once I made the mistake of thirstily polishing off a nearly-full 2-quart bottle of Ocean Spray Premium Prune Juice over the course of a couple hours on an especially hot day. Well, needless to say, I was then obliged to stay in the yard for the next couple days 'cuz I had to run inside and visit the Little Boys' Room every ten minutes, plus I hadda remember to not eat anything after four in the afternoon both days, so that I could eventually "poop myself empty" by late evening and thus be able to get some sleep at night! Talk about total colon-pee --- my poor butt-hole got so sore that it felt like I was squirtin' out hot lava towards the end of it! Ah, well --- live and learn --- prune juice isn't meant to be consumed in large quantities (I shoulda gotten a clue from the fact that the bottle had had so little used out of it), unlike apple or cranberry juice that comes in the same kind of bottle!
by QuacksO November 25, 2016
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The act of letting go a loud and powerful fart at the exact same moment with anyone.
Mike; Jen, you farted at the same time as Robin. Apparently you both have a" Colon Connection "
by ☆GENDA☆ May 19, 2016
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it's where you lose something in your ass, and someone else slurps it out
My friend lost their headphones in their ass, so I had to colon slurp them to get them out.
by CafeDonut November 7, 2019
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