A term that simply points out someones misfortune or lack of attaining or owning something they desire.
Big Jon: I want LSD and a Speed Cut Defencer

Beej: You have speedcut AND no LSD????? You loose!!!
by Beej December 05, 2004
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A phrase from an old NES game called Bokasuka Wars (which is regarded as the worst game ever by many). Whenever the player lost the game (which was quite often), the words "WOW, YOU LOSE" appaeared on-screen.
Player: *loses game*
Game: WOW, YOU LOSE!
by ShadowMan February 15, 2004
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an expression which states that anyone will miss out on a great opportunity if they don't remain aware or open to communication.
"I tried to call you about those concert tickets, but there was no answer...guess you were still crashed out.... so I took Marsha instead.
We had an awesome time, both at the show AND afterwards! :)"

"oh well, you snooze you lose I guess."
by hipster February 05, 2005
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A TERM THAT YOU'LL USE IF YOU OUT SMART OR CHEAT SOMEONE.
YOU SO DUMB YOU DON'T 2 + 2 SO, I WIN YOU LOSE
by TAYLORGANG TAE April 27, 2011
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A facebook-based image board with amusing, strange, insulting and horrifying content in equal measure. It takes the form of a game where you have to keep looking at new photos until one makes you laugh, which will invariably happen at some point or other.

Includes current popular 'memes' and a hefty does of racial, class, gender and sexuality based humour. In this sense it's like 4chan but a little less extreme due to everyone's identity being known. Pictures also often rely on members of the group's sense of Schadenfreude in relation to the stupid, the ugly and the recently deceased.
Yo did you check that guy's upload on You Laugh You Lose last night?
-Sure did, I made it about a dozen photos but then lost bad on that one about Heath Leger!
Ha - you're in it for the lulz bro!
by therizzlebizzle February 04, 2010
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The phrase used to describe an inopportune moment for ejaculation.
Bill: Hey, I'm going to have unprotected sex tonight.
Frank: Well, you splooge, you lose!

Sam: Damn it! I've got a boner in khakis for that hot bitch who's presenting in class today!
Ryan: Keep it cool, man. You splooge, you lose. And get weird looks for the rest of your life.

Barack Obama: Dang, the Chinese foreign minister is one sexy woman! How am I going to stand at the podium while she's 3 feet away from me?
Hillary Clinton: With all due respect, Mr. President, you splooge, you lose. And maybe also cause nuclear warfare.
by MarceltheGreat March 04, 2011
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An expression used at any random time to indicate epic fail, derived from Gene Wilder's line in Willy Wonka and the Chocolate Factory.
Brigitte: I read Twilight, New Moon, and Eclipse.

Me: You lose, good day sir!
by cacaivette November 19, 2007
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