When an individual is really pissed off at someone or something.
Wow! The boss sure has a case of the red ass today. He just fired Immanual.

Who gave John the case of the red ass?
by Digger August 21, 2005
classic phrase to be heard from the very very old people in the south, generally.

to mean pissed off. angry.
yo mawma sho got hahsayelf a cayas of da rayed ayss t'day.

your momma sure got herself a case of the red ass today.
by rachelgirlwonder September 23, 2005
pain and redness of the ass after a day of the shits
If i don't stop shitting. I'm going to have a case of the red ass.
by jay hamilton November 8, 2007
1: having a condition of being seriously pissed-off

2: the Accute-Stage of Angry-Blood.
"Get your dirty dick-beater prints off that brass ASAP before I get a case-of-the-red-ass"
by goodcop8 October 27, 2007