Okay..firstly lets get rid of all this americentrix bollocks. USA and Canada? East Coast? West Coast? All Bullshit. Twot is an old English word, in use before the American continent was settled. Yes, its just another word for Twat.

a female pussy

The way most Canadians pronounce the slang insult, "Twat".

Someone, who without effort, makes a right proper useless waste of space of himself. Not annoying, just a useless twot.

Twot, An abbreviation of, That Whore Over There, Is a more formal version of the popular slang, Thot, Which is and abbreviation of That Hoe Over There.
The term Twot, Was popularised by popular YouTuber 'The Right Opinion' He uses it stating that we should always use the Queens English, Even when using slang.

worst possible insult ever; not like it's bad, but it's stupid. people say it because they dont know any other insult. whoever says this most likely has a twat on their face. its also the gayest sounding insult ever.

Someone who tweets a lot.