1.) A city in the country of Mali, which is in Western Africa. Was once a major trade city and centre for Islamic religion in the 15th and 16th centuries. Mostly used nowadays as an expression, when people want to emphasise how isolated, inaccessible, far away or in the middle of nowhere a place is.

2.) A place that you didn't think actually existed, but it does.
Person 1: "You never come around to my house anymore."
Person 2: "Ho, that's because you live all the way out in Timbuktu."
Person 1: "That place doesn't even exist."
Person 2: "Does so."

*Person 1 goes to look it up*

Person 1: So it does!
by Lyosha May 11, 2009
A city in Mali, although it usually just refers to the middle of nowhere, or somewhere very far away.
"That's, like, all the way in Timbuktu!"
by CoolCrafter February 8, 2021
(noun) A city in the West African nation of Mali, known for its extreme inaccessibility. Now it is used to mean any extremely distant and inaccessible location.
We used to have each other over for dinner on a regular basis, but then she moved out to Timbuktu, and we haven't done it since.
by Moshe Jacobson November 9, 2004
Filipino term for anywhere or the extreme part of somewhere.
Termed after the city of Timbuktu, in Mali.
Announcer: Kahit nasaan ka man, mula, Luzon, Visayas, Mindanao, o kahit nasa Timbuktu ka man.
by Kay Tutan Tayo December 12, 2018
When you don't know someone from a specific area & a common exclamation referring to someone that you didn't even know from some random area that you happened to met.
Girl - So I let this person take care of my dog & let me tell you, it did not go out so well!
Guy - How so?
Girl - Well, just look at the dog! She's down to the bone!
Guy - That's why you don't trust strangers from Timbuktu to take care of your pets!
by JayJayJayIsTheWord April 25, 2016
recieving a blowjob while chewing tobacco
She gave me a timbuktu in the movie theatre while i was chewing with my boys.
by b_zero January 23, 2007
When a man and a woman roll into a ball and roll around naked in their home.
Dude my legs are so sore after I gave my girlfriend a timbuktu tumbleweed last night.
by D34th5grip August 19, 2017