1. An Italian -American hooker living in New York, more specifically in the Bronx region, during the 1960's, with her workplace coincidentally being located near a Italian food restaurant joint owned by a Cosa Nostra mobster, who most of thr times, tends ti be her pimp.

2. An abstract, nonsensical phrase. It can be used to replace basically any possible word.
"Man, yesterday I went to a spaghetti bitch who had the tightest pussy. To bad her pimp started bugging me when I left."

"Spaghetti bitch, man."
by Humble Jeremiah May 16, 2020
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When someone gets so attracted to a friend they become a Spaghetti substance in their presence.
Wow, I appear to be your Spaghetti Bitch
by HazardMacaroni October 18, 2022
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