Slime Tube Share definition Flag 1. A nasty, filthy place. 2. Slang term for a woman's naughty bits. 1. That back alley over there is such a Slime Tube! 2. That girl's Slime Tube made a cyst the other day. Slime Tube by Slime Tuber May 31, 2011 Get the Slime Tube mug.