What you sarcastically quip back at someone who is bemoaning da fact dat he wasted ten minutes of his life doing something dat turned out to be useless.
Dude #1 (having just super-briefly talked to customer-service after waiting an absurdly long time to get connected): Man, what an insufferable delay just being stuck on hold --- THAT'S ten minutes of my life that I'll never get back!
Dude #2: ...aaaand that's ANOTHER ten SECONDS that you'll never get back from COMPLAINING about it!
When you have to pee in a movie but don’t want to miss anything, and must do the following mental equation: will the amount I have to pee cause enough discomfort to diminish my attention capacity for the remainder of the movie to an extent which is greater than the amount of the movie I would miss by making a mad dash to the restroom.
I saw Satantango last night, wonderful film but by the 5th hour I had to start doing pee calculus.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).