Not unlike Plenty of Fish, POF also stands for Puddle of Flesh. POF is the substance that you turn in to and the sound that it makes when it happens.
Gordilia: "OMG! My BF just went POF!"

Larry: "What does that mean?"

Gordilia: "He turned in to a puddle of flesh!"

Larry: "Plop is the man who falls without bones!"
by ANOTHERDEADROMEO March 2, 2023
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