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"Premmed out" describes the appearence of a woman over 30, cougar, who uses Premarin to achieve a youthful, sensual appearence.

"Premmed" is derived from Premarin, the Hormone Replacement Therapy drug derived from Pregnant Mare Urine.

Premarin is one of the most prescribed drugs in the U.S.
"I was at the bar the other night and it was a cougar feeding frenzy. Some of these women are 50 and are so Premmed out that they look 30."
by Steven Gallanter December 18, 2007
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