There can be 4 meanings to the term piss off.
1. Yeah, totally. (Sarcasm)
2. Screw off, get lost.
3. To make someone mad/angry
4. A person whose job is to make people angry, a job done for pleasure.
1. "Yo, bro, I asked Megan out today. She said yes!"
"Piss off, you bitch"
2. "Who are you?"
"I'm James! You invited me to the jam!"
"Go piss off, I didn't invite you for shit."
3. "Hey, you shithead. You really pissed me off yesterday. It's time to pay."
4. "Greg, why are you being such a fucking piss off?"
by DefineModernShit November 04, 2014
Get the mug
Get a Piss off mug for your boyfriend Manafort.
To eliminate a hard-on (go limp) by peeing instead of ejaculation. This is disappointing to men, so they don't want to go to the bathroom and piss off their hard-on. Then then say they are pissed off, or angry about it.

It has become slang for making someone angry or when something or someone makes a person angry.

Today, women have picked up on this term also, using it as getting angry (but not about their hard-on going away).
I love my errection, but when I go pee it will piss off (original usage).
He is going to piss me off (modern).
by Jimmie Boy May 16, 2006
Get the mug
Get a piss off mug for your bunkmate Yasemin.
Any person who is constantly pissing you/others off or doing things to piss people off.
Wow that guy is such a piss off!

My ex is a piss off.
by Mz_Katie June 18, 2009
Get the mug
Get a Piss off mug for your Facebook friend Beatrix.
A race and timed event to see who can piss the longest after drinking a six pack of old milwakee while holding a glass of ice water thoughout the entire duration.
Gentlemen... let the Piss Off begin!
by Koola User September 04, 2003
Get the mug
Get a Piss Off mug for your Facebook friend Paul.