literally means "fuck off", but it sounds way cooler because not many people say it
Bill: hey Roger, what are you reading? a note?
Roger: piss off Bill!
by blakkmetal November 06, 2007
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When someone comes up and annoys you, you would tell them to piss off.
by bread infection November 25, 2009
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There can be 4 meanings to the term piss off.
1. Yeah, totally. (Sarcasm)
2. Screw off, get lost.
3. To make someone mad/angry
4. A person whose job is to make people angry, a job done for pleasure.
1. "Yo, bro, I asked Megan out today. She said yes!"
"Piss off, you bitch"
2. "Who are you?"
"I'm James! You invited me to the jam!"
"Go piss off, I didn't invite you for shit."
3. "Hey, you shithead. You really pissed me off yesterday. It's time to pay."
4. "Greg, why are you being such a fucking piss off?"
by DefineModernShit November 04, 2014
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A person who will potentially piss the shit out of you.
God, Jake is a total pissoff! I'm gonna' beat his ass!
by Remy Gaudin March 14, 2008
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To eliminate a hard-on (go limp) by peeing instead of ejaculation. This is disappointing to men, so they don't want to go to the bathroom and piss off their hard-on. Then then say they are pissed off, or angry about it.

It has become slang for making someone angry or when something or someone makes a person angry.

Today, women have picked up on this term also, using it as getting angry (but not about their hard-on going away).
I love my errection, but when I go pee it will piss off (original usage).
He is going to piss me off (modern).
by Jimmie Boy May 16, 2006
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Telling someone to get lost in rude way
A douche - looking guy at the party asked for my number and i told him to piss off.
by burst of confidence January 01, 2018
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