Permatweeked 

Former dope heads that still show signs of previous drug abuse by twitching, talking out the side of their face, may appear to be trying to bite their own ear...

Girl 1: "Damn, what the hell is wrong with that twitchy bitch?"
Girl #2: "Oh, don't pay her no mind, that bitch just permatweeked!"
Girl #1: "Whoa, I am not ever doing meth!!!"
Girl #2: "I know that's right..."

Permatweeked by heatedpoet July 9, 2016

permatweaker 

people who have been tweaked so long that they are now permanently tweaked out. aka life long crack head.

tommy has been a crack head for so long he has now gained the title of permatweaker.

permatweaker by bevis85 May 28, 2009

permatweaked

Permanently brain damaged from methamphetamine used. Also known as fried.

Fucker is permatweaked, jackjawing, looking out of the corner of his eyes, quick screwed up thinking, and not able to reason.

permatweaked by gayburns7 March 8, 2015

Permatwacked 

Permanently twacked out; the point of no return in twack land.

Dude, he's done so much dope he's permatwacked!

Permatwacked by Love, lm January 13, 2021