Permanently brain damaged from methamphetamine used. Also known as fried.
Fucker is permatweaked, jackjawing, looking out of the corner of his eyes, quick screwed up thinking, and not able to reason.
by gayburns7 March 8, 2015
Get the permatweaked mug.
people who have been tweaked so long that they are now permanently tweaked out. aka life long crack head.
tommy has been a crack head for so long he has now gained the title of permatweaker.
by bevis85 May 29, 2009
Get the permatweaker mug.