Mutley Slyrus Share definition Flag A skanky hoe, commonly called Miley Cyrus. Is still obsessed with Nick Jonas, even though they broke up a year ago. 'Omg did you hear about Mutley Slyrus??' "No, Whats that Skank done now!" Mutley Slyrus by Dee-Jay-Cee January 4, 2009 0 0 Get merch Get the Mutley Slyrus mug. Buy Now — $32.95 See more merch