Mrs. Numbnuts Share definition Flag A disparaging term used to indicate that a woman is not functioning on all cylinders. My mother, self-effacing comedian that she was, started to refer to herself as “Mrs. Numbnuts” as her cognition steadily declined. Mrs. Numbnuts by Dr Bunnygirl May 19, 2023 0 0 Get merch Get the Mrs. Numbnuts mug. Buy Now — $32.95 See more merch