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The couple name given to Grey's Anatomy characters Meredith Grey and Derek Shepherd. It's only used outside of the show, when fans are talking about them.
Did you see last night's episode of Grey's? You see that McDreamy moment? I love merder!
Merder by Maybelle29 July 3, 2009

len merde 

A slick haitian word meaning fuck off.
len merde by lil wade October 30, 2006
French for "shit". Suitable for describing just about everything in my life right now.
Rimbaud once scrawled "Merde a Dieu!" (shit on God) as graffiti in Paris.
merde by skyblack June 12, 2004

un sale rat de merde 

un sale rat de merde is basically a shitty human being, or a snitch. the biggest example is gaston, he's the rat king.
frr gaston c'est un sale rat de merde
"Ohhhhh...merde." - Spy, TF2
Merde by citizenjoe100 January 18, 2011
In addition to being French for, "shit", "Merde" is a term used by ballet dancers (male or female) before they go on stage. This is the equivalent to "break a leg" in theatre.
(imagine yourself backstage...)
"Hey, merde."
"...thanks"
merde by exupery May 13, 2005